cell proliferation

[Molecular Therapy Oncolytics] The authors identified that silencing LINC01296 repressed neuroblastoma cell proliferation and migration, and promoted apoptosis. LINC01296 knockdown inhibited tumor growth in vivo.

[Science Signaling] The authors investigated whether Themis plays a direct role in cytokine signaling in mature T cells.

[Cell Reports] Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Researchers probed the potential links among these cancer traits by inactivating TP53 in hESCs.

[Cell Reports] Aberrant genomic localization of DOT1L was implicated in mixed lineage leukemia-rearranged leukemias, an aggressive subset of leukemias that lacks effective targeted treatments.

[Nature Communications] Researchers demonstrated how direct and indirect contact with allogenic MSCs improves regulatory T cells' (Tregs) potential for accumulation of immunosuppressive adenosine and suppression of conventional T cell proliferation, making them more potent therapeutic tools.

[Journal of Hazardous Materials] Scientists synthesized surfactant-free amine-functionalized polystyrene (PS) nanoparticles (NPs) and PS-NPs with decreased crosslinking density without changing other factors, such as size, shape, and zeta potential and examined their effects on cell viability and physiology.