cell proliferation

[Stem Cell Research & Therapy] The impact of human MuStem cells or their secretome on the proliferative and phenotypic properties of T cells was explored by co-culture experiments with either peripheral blood mononucleated cells or CD3-sorted T cells.

[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.

[Scientific Reports] Investigators established a model of CSCs that was originally developed from mouse induced pluripotent stem cells (miPSCs) by proposing miPSCs to the conditioned medium of cancer derived cells, which was a mimic of carcinoma microenvironment.

[Cell Death & Disease] Researchers identified neurokinin-1 as a significantly upregulated GPCR in the transcriptome and tissue array of human lung cancer samples, associated with advanced clinical stages and poor prognosis.

[Journal of Cancer] Researchers investigated the high level of EIF3J‐AS1 in prostate cancer (PCa) tissues and cells, and used functional assays to show that knocking down EIF3J‐AS1 inhibited PCa cell proliferation and metastatic ability.

[International Journal of Cancer] Investigators showed that ablation of type I fibroblast growth factor receptor (FGFR1) in DU145 human prostate cancer cells changed the cell metabolite profile. Among the changes, the choline metabolism profile was the most significantly altered by FGFR1 ablation.