cell proliferation

[Journal of Gene Medicine] Expression of circular RNA derived from dipeptidyl peptidase 4 (circDPP4) was upregulated in prostate cancer (PC) tumors from 60 patients and PC cell lines, and higher circDPP4 might predict poor overall survival. Decreasing circDPP4 suppresses cell proliferation, colony formation, migration/invasion, and 50% inhibitory concentration of docetaxel in PC cells.

[Journal of Oncology] The authors investigated the role of miR-145-5p in prostate cancer (PCa) and its potential molecular mechanisms and confirmed that miR-145-5p inhibited the growth and metastasis of PCa cells by inhibiting the expression of proto-oncogene WIP1.

[Journal of Cellular Biochemistry] MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation.

[Toxicology] Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on hESC proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.

[Oncology Let] Scientists elucidated the role of ZNF750 in the inhibition of the renewal ability of CSCs derived from the oral squamous cell carcinoma cell line, CAL‑27.

[Cell Death Discovery] Synaptotagmin-8 (SYT8) is a membrane protein that regulates hormone secretion and neurotransmission, and its expression is positively regulated by the promoter of the insulin gene in pancreatic islet cells. Researchers identified a previously unknown role of SYT8 in altering tumor characteristics in pancreatic cancer.