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cell proliferation

FAM49B Promotes Breast Cancer Proliferation, Metastasis, and Chemoresistance by Stabilizing ELAVL1 Protein and Regulating Downstream Rab10/TLR4 Pathway

[Cancer Cell International] Scientists systematically studied the role of FAM49B in the proliferation, metastasis, apoptosis, and chemoresistance of breast cancer, as well as the corresponding molecular mechanisms and downstream target.

The Transcription Factor NF-Y Participates to Stem Cell Fate Decision and Regeneration in Adult Skeletal Muscle

[Nature Communications] Researchers reported that satellite cells, the stem cell population of adult skeletal muscle necessary for its growth and regeneration, expressed uniquely the longer NF-YA isoform, majorly associated with cell differentiation.

Dynamic Changes in tRNA Modifications and Abundance during T Cell Activation

[Proceedings of the National Academy of Sciences of the United States of America] Scientists examined the tRNA and mRNA pools of T cells during their vigorous proliferation and differentiation upon triggering their antigen receptor.

Protein Co-Expression Network-Based Profiles Revealed from Laser-Microdissected Cancerous Cells of Lung Squamous-Cell Carcinomas

[Scientific Reports] Researchers unveiled disease-related protein networks by proteomic and bioinformatic assessment of laser-microdissected cancerous cells from seven lung squamous cell cancer compared with eight representative lung adenocarcinomas.

DRAIC Promotes Growth of Breast Cancer by Sponging miR-432-5p to Upregulate SLBP

[Cancer Gene Therapy] Investigators conducted a qRT-PCR assay to measure the expression of downregulated RNA in cancer (DRAIC) and other downstream target genes. They uncovered that DRAIC was expressed at a high level in breast cancer cells.

FBXW11 Contributes to Stem-Cell-Like Features and Liver Metastasis through Regulating HIC1-Mediated SIRT1 Transcription in Colorectal Cancer

[Cell Death & Disease] The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.

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