chondrocytes

[Applied Materials Today] Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.

[Advanced Science] Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (ECM), which were further preserved in acellular cartilaginous ECM following mild, short-period decellularization.

[NPJ Regenerative Medicine] Investigators described the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human PSC-derived articular chondrocyte formulation that exhibited long-term functional repair of porcine articular cartilage.

[Scientific Reports] Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).

[Scientific Reports] Researchers examined the host cells that promoted cartilage maturation via cell–cell contact. Based on analysis of the transplanted chondrocytes, they examined the contribution of endothelial cells and macrophages.

[NPG Asia Materials] Researchers developed a hydrogel system that could release first stromal cell-derived factor-1 and then kartogenin in a unique sequential drug release mode, which could spatiotemporally promote the recruitment and chondrogenic differentiation of MSCs.