chronic inflammation

[Laboratory Investigation] Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.

[Cellular & Molecular Immunology] Scientists discuss the role of inflammation in initiating epigenetic alterations in immune cells, cancer-associated fibroblasts, and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.

[Aging Cell] Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.

[iScience] Utilising an in vitro migration assay, regulatory T cells from patients with psoriatic arthritis treated with conventional therapy paradoxically boosted CCR6+ effector T cell migration towards CCL20.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Nature Reviews Immunology] The authors review key molecular mechanisms of immune cell activation implicated in modulating atherogenesis and provide an update on the contributions of innate and adaptive immune cell subsets in atherosclerosis.