colorectal cancer

[ImmunoScape] ImmunoScape announced that it has signed a licensing deal with Pure MHC, LLC, a target discovery and development company, to pursue TCR-T therapeutics against Pure MHC-identified antigens in lung cancer, colorectal cancer, and other cancer indications.

[Oncogene] Scientists demonstrated that oncogenic LINC021 specifically bound with the m6A “reader” IMP2 protein and enhanced the mRNA stability of MSX1 and JARID2 in an m6A regulatory manner during CRC tumorigenesis and pathogenesis.

[British Journal of Cancer] Mutational tumour profile was examined using a customised gene panel. Immunofluorescence was used to identify the cellular location of punctate IKKα expression.

[Clinical and Experimental Medicine] The efficacy of selumetinib in various solid tumors such as colorectal cancer, lung cancer, neurofibroma, and melanoma is investigated.

[Advanced Science] The authors showed that Fusobacterium nucleatum promoted colorectal cancer stem-like cells (CCSCs) self-renewal, and non-CCSCs to acquire CCSC features by manipulating cellular lipid accumulation.

[Experimental & Molecular Medicine] Researchers validated that these genes have oncogenic features in colorectal cancer and that their expression levels were increased in correlation with the hypermethylation of intragenic regions.