Home Newsletters Intestinal Cell News LINC01021 Maintains Tumorigenicity by Enhancing N6-Methyladenosine Reader IMP2 Dependent Stabilization of MSX1...

LINC01021 Maintains Tumorigenicity by Enhancing N6-Methyladenosine Reader IMP2 Dependent Stabilization of MSX1 and JARID2: Implication in Colorectal Cancer

Justin.choi

February 17, 2022

Scientists demonstrated that oncogenic LINC021 specifically bound with the m⁶A “reader” IMP2 protein and enhanced the mRNA stability of MSX1 and JARID2 in an m⁶A regulatory manner during CRC tumorigenesis and pathogenesis.

[Oncogene]

Abstract