crystallography

[Science Advances] Scientists demonstrated that the minimal Pmt unit necessary for PSM export is PmtCD and provided its first atomic characterization by single-particle cryo-EM and x-ray crystallography. They have captured the transporter in the ATP-bound state at near atomic resolution, revealing a type II ABC exporter fold, with an additional cytosolic domain.

[iScience] Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.

[Acta Pharmacologica Sinica] The authors showed that either the oral liquid of Shuanghuanglian, the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-2 3CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.