Tag results:
cyclooxygenase-2
Dermal Cell News
E3 Ubiquitin Ligase HECTD2 Mediates Melanoma Progression and Immune Evasion
[Oncogene] Identified through screening for cancer-specific endogenous retroviral transcripts, scientists showed that the little-studied E3 ubiquitin ligase HECTD2 exerted dominant control of tumor progression in melanoma.
Cell Therapy News
Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival
[Scientific Reports] The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
Endothelial Cell News
Loss of Diacylglycerol Kinase ε Causes Thrombotic Microangiopathy by Impairing Endothelial VEGFA Signaling
[JCI Insight] By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate.
Muscle Cell News
Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress
[Biochemical Pharmacology] Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.
Mammary Cell News
Identification of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition
[Breast Cancer Research] Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.
Pulmonary Cell News
Inhibition of Inflammation-Induced Injury and Cell Migration by Coelonin and Militarine in PM2.5-Exposed Human Lung Alveolar Epithelial A549 Cells
[European Journal of Pharmacology] Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PM2.5.