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cyclooxygenase-2

E3 Ubiquitin Ligase HECTD2 Mediates Melanoma Progression and Immune Evasion

[Oncogene] Identified through screening for cancer-specific endogenous retroviral transcripts, scientists showed that the little-studied E3 ubiquitin ligase HECTD2 exerted dominant control of tumor progression in melanoma.

Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival

[Scientific Reports] The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.

Loss of Diacylglycerol Kinase ε Causes Thrombotic Microangiopathy by Impairing Endothelial VEGFA Signaling

[JCI Insight] By generating a potentially novel endothelial specific Dgke-knockout mouse, researchers demonstrated that loss of Dgke in the endothelium resulted in impaired signaling downstream of VEGFR2 due to cellular shortage of phosphatidylinositol 4,5-biphosphate.

Valdecoxib Improves Lipid-Induced Skeletal Muscle Insulin Resistance via Simultaneous Suppression of Inflammation and Endoplasmic Reticulum Stress

[Biochemical Pharmacology] Scientists suggest that valdecoxib alleviated insulin resistance through AMP-activated protein kinase/heat shock protein beta 1-mediated inhibition of inflammation and endoplasmic reticulum stress in skeletal muscle under hyperlipidemic conditions.

Identification of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition

[Breast Cancer Research] Scientists identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. Furthermore, they found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both In Vitro and In Vivo.

Inhibition of Inflammation-Induced Injury and Cell Migration by Coelonin and Militarine in PM2.5-Exposed Human Lung Alveolar Epithelial A549 Cells

[European Journal of Pharmacology] Investigators evaluated the anti-inflammatory properties of coelonin and militarine and examined their underlying molecular mechanisms in A549 cells exposed to PM2.5.

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