dendritic cells

[Science Immunology] Researchers used single-cell multiomics, transgenic murine models, and functional approaches to define extrathymic Aire-expressing cells at the transcriptional, genomic, and proteomic level.

[Frontiers in Endocrinology] The authors differentiated iPSC from one donor into dendritic cells, macrophages, endothelial cells, and β-cells, and engineered T cell avatars from the same donor to provide an in vitro platform to study genetic influences on critical cellular interactions.

[Proceedings of the National Academy of Sciences of the United States of America] Although the gene expression programs of early–B and early–T lymphocyte development are mutually exclusive, investigators showed that these cell types exhibit significantly correlated microRNA profiles.

[Journal of Neuroinflammation] There is increasing evidence that dendritic cells (DCs) are implicated as key modulators in keeping the balance between immune response and tolerance in the central nervous system.

[Heliyon] Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.

[Science Immunology] The authors showed that effective induction of T cell responses against influenza A virus in mice requires reinforcement of the resident lung conventional dendritic cells (cDC) network by cDC progenitors.