dendritic cells

[Scientific Reports] Loss of Cdx function led to a rapid and pronounced attenuation of H2-T3, followed by a decrease in iCD8α cell number, an increase in macrophage infiltration and activation of pro-inflammatory cascades, suggesting a previously unrecognized role for Cdx in intestinal homeostasis through H2-T3-dependent regulation of iCD8α cells.

[Cell] The authors showed that the conversion of stem-like into effector-like cytotoxic T lymphocyte involved a major chemotactic reprogramming that included the upregulation of chemokine receptor CXCR6.

[Blood] Interferon-producing Siglec H-positive bone marrow immune cells engaged with O-glycan sialic acid moieties to regulate type I interferon secretion and platelet release, as evidenced by partially normalized platelet count following and inhibition of interferon and Siglec H receptors.

[Immunity] Researchers focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes.

[Bone Marrow Transplantation] Investigators evaluated the immune reconstitution of patients receiving omidubicel grafts during the first six months post-transplant, as IR is critical for favorable outcomes of the procedure.

[Nanomedicine-Nanotechnology Biology and Medicine] A DNA vaccine was efficiently uptaken by dendritic cells and induced effective immune response against mouse melanoma cells, leading to significant inhibition of melanoma tumor growth and reduction of lung metastasis in a mouse model.