dendritic cells

[Communications Biology] With a mycobacterial immunogen, scientists observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5-immunized mice, despite comparable antigen-specific CD8+ T cell magnitudes.

[Clinical Cancer Research] A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.

[Damon Runyon Cancer Research Foundation] (Peter) Geon Kim, MD, with mentor Benjamin L. Ebert, MD, PhD, at the Dana-Farber Cancer Institute, was one of five recipients of the 2021 Damon Runyon Physician-Scientist Training Award. Dr. Kim's research may provide insight into various inflammatory conditions associated with clonal hematopoiesis and potentially elucidate how clonal hematopoiesis progresses into blood cancer.

[Cell] Investigators showed that secreted gelsolin, an extracellular protein, decreased DNGR-1 binding to F-actin and cross-presentation of dead cell-associated antigens by type 1 conventional dendritic cells.

[British Journal of Haematology] Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.

[Stem Cells] Investigators probed the effect of the Zbtb46 transcription factor in ESC-derived blood cell progenitors using chemically inducible mouse cell lines.