dermal cells

[Cell Death & Disease] The authors review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions.

[Cell Reports] Researchers showed that the RNA-binding protein UNR/CSDE1 enabled oncogene-induced senescence in primary mouse keratinocytes.

[Cancer Gene Therapy] Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.

[Scientific Reports] Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.

[Inflammation] Researchers evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.

[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.