endothelial cells

[Scientific Reports] Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and VEGF A. Lyve1-expressing macrophages promoted the migration and tube formation of HUVECs.

[Annals of Medicine] The authors comprehensively review the role of high-mobility group box 1 (HMGB1), hypoxia-inducible factor-1α (HIF-1α), and VEGF in doxorubicin-induced cardiovascular disease and its molecular mechanisms.

[Life Sciences] Scientists provide a comprehensive overview of how hyperglycemia in type 2 diabetes reprograms endothelial epigenome and lead to functional consequences in the pathogenesis of vascular complications.

[Nature Biomedical Engineering] Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.

[Advanced Science] Investigators developed in vitro methods using a kidney decellularized ECM hydrogel to culture human pluripotent stem cell-derived kidney organoids, which had extensive vascular network and their own endothelial cells.

[Advanced Science] The assembly of self-organizing 3D kidney-like structures was observed. Kidney organoids contain podocytes, proximal tubules, and endothelial cells that form networks of capillary loop-like structures.