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epithelial cells

Breast Tissue Regeneration Is Driven by Cell-Matrix Interactions Coordinating Multi-Lineage Stem Cell Differentiation through DDR1

[Nature Communications] Investigators engineered a 3D biomimetic human breast that made it possible to study how stem cell fate decisions translated to tissue-level structure and function.

Lactobacillus plantarum Alleviates Irradiation-Induced Intestinal Injury by Activation of FXR-FGF15 Signaling in Intestinal Epithelia

[Journal of Cellular Physiology] Scientists characterized that Lactobacillus plantarum activated the farnesoid X receptor – fibroblast growth factor 15 signaling in intestinal epithelial cells and hence promoted DNA-damage repair.

Enhanced Apoptosis as a Possible Mechanism to Self-Limit SARS-CoV-2 Replication in Porcine Primary Respiratory Epithelial Cells in Contrast to Human Cells

[Cell Death Discovery] Researchers investigated species-specific cell susceptibility, virus dose-dependent infectivity, and infection kinetics, using primary human and porcine respiratory epithelial cells.

Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

[Bioengineered] Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.

Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.

Parity-Induced Changes to Mammary Epithelial Cells Control NKT Cell Expansion and Mammary Oncogenesis

[Cell Reports] The authors illustrated how pregnancy-induced changes modulate the communication between mammary epithelial cells and the immune microenvironment and established a causal link between pregnancy, the immune microenvironment, and mammary oncogenesis.

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