epithelial cells

[NPJ Regenerative Medicine] The authors showed that in response to extensive hepatocyte damages, expression of dnmt1 was upregulated in biliary epithelial cells (BECs) to methylate DNA at the p53 locus, which repressed p53 transcription, and in turn, derepressed mTORC1 signaling to activate BEC dedifferentiation.

[Nature Communications] The authors reported that vaccinia C7 was a crucial virulence factor that blocked activation of the transcription factor IRF3.

[Prostate] Investigators analyzed the carcinogenetic potential of exposure to GHRH of a nontumor human prostate epithelial cell line (RWPE-1) as well as its transforming effect in a xenograft model.

[Oncology Reports] The authors investigated the use of designed ankyrin repeat protein Ec1 for targeted delivery of Pseudomonas exotoxin A variant (LoPE) with low immunogenicity and low non‑specific toxicity to epithelial cell adhesion molecule‑expressing prostate cancer cells.

[Gut Pathogens] Chronic colitis models of CagA+ H. pylori-colonized mice treated with 2% Dextran sulphate sodium were established to assess the disease activity and pertinent expression of tight junction proteins closely related to mucosal integrity.

[Immunity] Investigators identified Sh2d6 as a signature marker for CD45+ Tuft-2 cells. Depletion of Tuft-2 cells resulted in susceptibility to bacterial infection.