epithelial cells

[Scientific Reports] Scientists characterized the immune processes induced by the epithelium after urban particulate matter exposure in special regard to interactions with monocyte-derived dendritic cells and monocyte-derived macrophages in obstructive lung diseases.

[World Journal of Stem Cells] The authors discuss the mechanistic effects of MSCs with a focus on human amniotic epithelial cells, which can be used to treatment and improvement of outcome in multiple sclerosis disease.

[Trends in Immunology] Scientists discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (intestinal epithelial cells and type-3 innate lymphoid cells) determine how the intestinal barrier and host–microbiota–pathogens connections are molded.

[Scientific Reports] Scientists developed an in vitro intestinal monolayer model using two human colonic epithelial cell lines, Caco-2 and HT-29, co-cultured in Transwell inserts, and investigated the effects of heat treatment and/or hypoxia on the epithelial barrier function.

[Cell Reports] Researchers generated intestinal epithelial cell (IEC)-specific RNA helicase DEAH-box helicase 15 (DHX15)-knockout mice and demonstrated that DHX15 was required for controlling intestinal inflammation. Mechanistically, DHX15 interacted with NLRP6 to trigger NLRP6 inflammasome assembly and activation for inducing IL-18 secretion in IECs.

[Nature Communications] The authors showed that persistent oncogenic RAS signaling caused highly metastatic triple-negative mammary tumors in mice. The continuous signaling of oncogenic RAS played a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells.