DHX15 Is Required to Control RNA Virus-Induced Intestinal Inflammation

Researchers generated intestinal epithelial cell (IEC)-specific RNA helicase DEAH-box helicase 15 (DHX15)-knockout mice and demonstrated that DHX15 was required for controlling intestinal inflammation. Mechanistically, DHX15 interacted with NLRP6 to trigger NLRP6 inflammasome assembly and activation for inducing IL-18 secretion in IECs.