epithelial cells

[Communications Biology] Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.

[iScience] Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.

[Cell Death & Differentiation] Scientists examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in inflammatory bowel disease (IBD) patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.

[Viruses-Basel] The authors provide an overview of neutrophil characteristics, their classic effector functions, as well as more recently described antibody-mediated effector functions.

[Nature Biomedical Engineering] Scientists showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

[Biology of Reproduction] Researchers investigated the expression and distribution of the main components of the serotoninergic system in human amniotic tissue and in human amniotic epithelial cells in vitro, as an alternative model of early human embryo development.