RNF20 and RNF40 Regulate Vitamin D Receptor-Dependent Signaling in Inflammatory Bowel Disease

Scientists examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in inflammatory bowel disease (IBD) patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.