fibroblasts

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Scientific Reports] Scientists investigated the possibility that periostin secreted by fibroblasts derived from idiopathic pulmonary fibrosis lung might have affected proliferation of non-small cell lung cancer cells.

[Oncogene] The long non-coding RNA, HOX antisense intergenic RNA (HOTAIR), is a well-characterized oncogene in multiple human cancers, but not in cutaneous squamous cell carcinoma (CSCC). In this study, researchers investigated the potential role of HOTAIR in the stemness of CSCC.

[Scientific Reports] Researchers clarified how NKIRAS acted on cellular transformation, and generated transgenic mice in which NKIRAS2 was forcibly expressed using a cytokeratin 15 promoter, which was mainly activated in follicle bulge cells.

[Molecular Therapy] Scientists revealed that MSC-derived exosomes resided specifically in the injured kidney and delivered miRNA-34c-5p to reduce cellular activation and renal interstitial fibrosis by inhibiting core fucosylation.

[Molecular Genetics and Metabolism Reports] Investigators demonstrated the generation of Mucopolysaccharidosis type IIIA (MPS IIIA) iPSCs, and neural progenitor cells, the latter of which display reduced proliferation and neurogenic capacity.