fibroblasts

[Cell Death & Disease] Rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from epicardial adipose tissue (EAT) of rats in the myocardial infarction 4-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species levels.

[Burns & Trauma] Scientists found out how the conditioned medium of adipose-derived stem cells exerted an anti-fibrotic effect in keloid dermis-derived fibroblasts.

[Scientific Reports] Scientists evaluated the effects of noncytotoxic doses of irinotecan or its active metabolite SN38 on collagen production in systemic sclerosis fibroblasts.

[Scientific Reports] Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.

[Scientific Reports] The authors constructed an artificial vascular tissue constructed by human adipose tissue-derived stromal cells and umbilical vein-derived endothelial cells by a modified technique with cryopreservation.

[Nature Protocols] Researchers presented a multiplexed mass cytometry protocol for single-cell analysis of post-translational modification signaling and cell states in organoids and organoids co-cultured with fibroblasts and leukocytes.