gene knockout

[NPJ Regenerative Medicine] A set of formulations consisting of photo-polymerizable Gel; photo-polymerizable hyaluronic acid, and allogenic decellularized cartilage matrix, was synthesized and characterized.

[Cell Death & Disease] Scientists demonstrated that the prototypical Smac mimetic BV6 cooperated with the stimulator of interferon genes ligand 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate to trigger necroptosis in apoptosis-deficient pancreatic cancer cells

[Life Sciences] Scientists investigated the relationship between melanin production and lipofuscin synthesis in normal mouse melanoma cell line B16F1 cells and Tyrosinase gene knockout cells.

[Trends in Pharmacological Sciences] Myocardial ischemia or reperfusion increases the generation of reactive oxygen species from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation.

[International Journal of Molecular Sciences] Investigators generated a ubiquitin-specific protease 3 gene knockout using the CRISPR/Cas9 system and demonstrated that USP3 acts as a protein stabilizer of Oct4 by deubiquitinating Oct4.

[Journal of Pharmacological Sciences] The I/R liver injury rat model and the primary hepatocyte hypoxia/reoxygenation injury model were established. The biochemical indexes, inflammatory factor indexes, Th17/Treg balance and energy metabolism were evaluated.