genetic screen

[Nature] The combination of the epidermal growth factor receptor (EGFR) inhibitor gefitinib and lenvatinib displayed potent anti-proliferative effects in vitro in liver cancer cell lines that expressed EGFR.

[Science] Scientists found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice.

[Cancer Research] Reserachers showed inhibition of glucose metabolism with low dose 2-deoxyglucose in combination with a MEK inhibitor induced apoptosis in KrasG12D-driven pancreatic ductal adenocarcinoma cells in vitro.

[Nature] Scientists defined a critical period in a developing Drosophila motor circuit and identified astrocytes as essential for proper critical period termination.

[Oncogenesis] Researchers identified the deubiquitinase USP19 and demonstrated that its silencing reduces the migratory and invasive potential of highly invasive breast cancer cell lines.

[Nature Communications] Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.