glioblastoma cells

[Stem Cell Research & Therapy] Scientists explored the effect and mechanism of glioma-associated MSCs on resistance to temozolomide in glioma cells.

[Cancer Cell] Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

[Cell Death & Disease] Investigators demonstrated that Arrb2 interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL.

[Nmr in Biomedicine] Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.

[Scientific Reports] Transient overexpression of miR-138 in glioblastoma cells inhibited cell proliferation, cell cycle, migration, and wound healing capability.The authors unveiled that miR-138 negatively regulated the expression of CD44 by directly binding to the 3′ UTR of CD44.

[Cell Death Discovery] Both tumor suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Investigators performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.