Both tumor suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Investigators performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
[Cell Death Discovery]
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Recasens, A., Humphrey, S. J., Ellis, M., Hoque, M., Abbassi, R. H., Chen, B., Longworth, M., Needham, E. J., James, D. E., Johns, T. G., Day, B. W., Kassiou, M., Yang, P., & Munoz, L. (2021). Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00456-6 Cite