MicroRNA-138 Suppresses Glioblastoma Proliferation through Downregulation of CD44

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Transient overexpression of miR-138 in glioblastoma cells inhibited cell proliferation, cell cycle, migration, and wound healing capability.The authors unveiled that miR-138 negatively regulated the expression of CD44 by directly binding to the 3′ UTR of CD44.
[Scientific Reports]
Yeh, M., Wang, Y.-Y., Yoo, J. Y., Oh, C., Otani, Y., Kang, J. M., Park, E. S., Kim, E., Chung, S., Jeon, Y.-J., Calin, G. A., Kaur, B., Zhao, Z., & Lee, T. J. (2021). MicroRNA-138 suppresses glioblastoma proliferation through downregulation of CD44. Scientific Reports, 11(1), 9219. https://doi.org/10.1038/s41598-021-88615-8 Cite
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