glioblastoma

[Nature Communications] Researchers showed that genetic and pharmacological Aurora kinase A inhibition elicited metabolic reprogramming mediated by inhibition of MYC targets and concomitant activation of Peroxisome Proliferator Activated Receptor Alpha signaling.

[Acta Pharmacologica Sinica] By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.

[Biochimica et Biophysica Acta-Reviews On Cancer] Scientists summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.

[Cell Cycle] Investigators explored the role and underlying mechanism of miR-663a in the proliferation, migration, invasion, and cancer stem cell-like properties of glioma cells.

[Nature Cancer] Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.

[npj Flexible Electronics] Scientists showed with fluorescence widefield and multiphoton microscopy that pulsed electric fields induced vasoconstriction of blood vessels and evoked calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence reporter.