glioblastoma

[Nature Communications] Researchers identified and validated the presence of hematopoietic stem and progenitor cells (HSPCs) within glioblastoma tissues, and demonstrated a positive link of tumor-associated HSPCs with malignant and immunosuppressive phenotypes.

[Nature Communications] The authors discovered that prohibitin specifically regulated mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.

[Nature Communications] Scientists identified and validated the presence of hematopoietic stem and progenitor cells within glioblastoma tissues.

[Journal of Clinical Investigation] Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Investigators elaborate on all mentioned contradictory data and provides a realistic, current clinical perspective on MSCs' potential in glioblastoma treatment.

[Nature Communications] To identify the host cell factors involved, the authors carry out siRNA library screening using a druggable genome library. They identify one crucial modulator of H-1PV infection: laminin γ1.