Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
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Shaim, H., Shanley, M., Basar, R., Daher, M., Gumin, J., Zamler, D. B., Uprety, N., Wang, F., Huang, Y., Gabrusiewicz, K., Miao, Q., Dou, J., Alsuliman, A., Kerbauy, L. N., Acharya, S., Mohanty, V., Mendt, M., Li, S., Lu, J., … Rezvani, K. (2021, June 17). Targeting the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells. https://doi.org/10.1172/JCI142116 Cite