graft-versus-host disease

[Bone Marrow Transplantation] Investigators compared outcomes using HLA-matched unrelated donors versus haploidentical donors in a relapsed acute lymphoblastic leukemia population.

[Cancer Medicine] To evaluate the tolerance and efficacy of prophylactic donor lymphocyte infusion in patients with unfavourable gene mutations such as FLT3‐ITD, TP53, ASXL1, DNMT3A or TET2, scientists performed a prospective, single‐arm study.

[Frontiers in Cell and Developmental Biology] Investigators explore the several mechanisms through which MSCs impact on the supportive activity of the bone marrow niche and regulate hematopoietic stem and progenitor cell homeostasis.

[Hematological Oncology] To investigate the potential influence of killer cell immunoglobulin‐like receptor (KIR) matching and mesenchymal stem cells, and their synergism on acute and chronic graft‐versus‐host disease after allo‐hematopoietic stem cell transplantation in acute myeloid leukemia and acute lymphoblastic leukemia patients.

[Journal of Clinical Investigation] Researchers utilized T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate acute graft-versus-host disease.

[Frontiers in Immunology] CTLA4-chimeric antigen receptor T cells were found to accumulate in tumors and are toxic to myeloid-derived suppressor cells without signs of severe GVHD and CRS in preclinical models.