To evaluate the tolerance and efficacy of prophylactic donor lymphocyte infusion in patients with unfavourable gene mutations such as FLT3‐ITD, TP53, ASXL1, DNMT3A or TET2, scientists performed a prospective, single‐arm study.
[Cancer Medicine]
6445218 {6445218:7IDF82S5} apa 50 1 161865 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-cb66357fee4c68170d16349778806803%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227IDF82S5%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20R.%2C%20Wang%2C%20L.%2C%20Chen%2C%20P.%2C%20Gao%2C%20X.%2C%20Wang%2C%20S.%2C%20Li%2C%20F.%2C%20Dou%2C%20L.%2C%20Gao%2C%20C.%2C%20Li%2C%20Y.%2C%20%26amp%3B%20Liu%2C%20D.%20%28n.d.%29.%20Haematologic%20malignancies%20with%20unfavourable%20gene%20mutations%20benefit%20from%20donor%20lymphocyte%20infusion%20with%5C%2Fwithout%20decitabine%20for%20prophylaxis%20of%20relapse%20after%20allogeneic%20HSCT%3A%20A%20pilot%20study.%20%3Ci%3ECancer%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3763%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3763%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D7IDF82S5%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Haematologic%20malignancies%20with%20unfavourable%20gene%20mutations%20benefit%20from%20donor%20lymphocyte%20infusion%20with%5C%2Fwithout%20decitabine%20for%20prophylaxis%20of%20relapse%20after%20allogeneic%20HSCT%3A%20A%20pilot%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lili%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peng%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoning%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuhong%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fei%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liping%22%2C%22lastName%22%3A%22Dou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunji%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daihong%22%2C%22lastName%22%3A%22Liu%22%7D%5D%2C%22abstractNote%22%3A%22Relapse%20is%20the%20main%20cause%20of%20treatment%20failure%20for%20leukaemia%20patients%20with%20unfavourable%20gene%20mutations%20who%20receive%20allogeneic%20haematopoietic%20stem%20cell%20transplantation%20%28allo-HSCT%29.%20There%20is%20no%20consensus%20on%20the%20indication%20of%20donor%20lymphocyte%20infusion%20%28DLI%29%20for%20prophylaxis%20of%20relapse%20after%20allo-HSCT.%20To%20evaluate%20the%20tolerance%20and%20efficacy%20of%20prophylactic%20DLI%20in%20patients%20with%20unfavourable%20gene%20mutations%20such%20as%20FLT3-ITD%2C%20TP53%2C%20ASXL1%2C%20DNMT3A%20or%20TET2%2C%20we%20performed%20a%20prospective%2C%20single-arm%20study.%20Prophylactic%20use%20of%20decitabine%20followed%20by%20DLI%20was%20planned%20in%20patients%20with%20TP53%20or%20epigenetic%20modifier%20gene%20mutations.%20The%20prophylaxis%20was%20planned%20in%2046%20recipients%3A%20it%20was%20administered%20in%2028%20patients%20and%20it%20was%20not%20administered%20in%2018%20patients%20due%20to%20contraindications.%20No%20DLI-associated%20pancytopenia%20was%20observed.%20The%20cumulative%20incidences%20of%20grade%20II%5Cu2013IV%20and%20III%5Cu2013IV%20acute%20graft-versus-host%20disease%20%28GVHD%29%20at%20100%20days%20post-DLI%20were%2025.8%25%20and%2011.0%25%2C%20respectively.%20The%20rates%20of%20chronic%20GVHD%2C%20non-relapse%20mortality%20and%20relapse%20at%203%20years%20post-DLI%20were%2021.6%25%2C%2025.0%25%20and%2026.1%25%2C%20respectively.%20The%203-year%20relapse-free%20survival%20and%20overall%20survival%20%28OS%29%20rates%20were%2048.9%25%20and%2048.2%25%2C%20respectively.%20Acute%20GVHD%20%28HR%3A%202.30%2C%20p%20%3D%200.016%29%20and%20relapse%20%28HR%3A%202.46%2C%20p%20%3D%200.003%29%20after%20DLI%20were%20independently%20associated%20with%20inferior%20OS.%20Data%20in%20the%20current%20study%20showed%20the%20feasibility%20of%20prophylactic%20DLI%20with%5C%2Fwithout%20decitabine%20in%20the%20early%20stage%20after%20allo-HSCT%20in%20patients%20with%20unfavourable%20gene%20mutations.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fcam4.3763%22%2C%22ISSN%22%3A%222045-7634%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fcam4.3763%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-04T17%3A45%3A43Z%22%7D%7D%5D%7D
Zhang, R., Wang, L., Chen, P., Gao, X., Wang, S., Li, F., Dou, L., Gao, C., Li, Y., & Liu, D. (n.d.). Haematologic malignancies with unfavourable gene mutations benefit from donor lymphocyte infusion with/without decitabine for prophylaxis of relapse after allogeneic HSCT: A pilot study. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3763 Cite