granulocytes

[Bone Marrow Transplantation] Investigators retrospectively analyzed 657 patients with primary or secondary myelofibrosis transplanted with use of peripheral blood stem cells after fludarabine/melphalan or fludarabine/busulfan RIC regimen.

[Blood Advances] The authors indicated that Cebpa-enhancer deletion caused cell autonomous neutropenia, which reprogramed and disturbed the quiescence of HSCs, leading to a systemic impairment of the hematopoietic process.

[Cellular & Molecular Immunology] Increased Metrnβ effectively blocked the development of airway hyperreactivity and decreased inflammatory cell airway infiltration and type 2 cytokine production, which was associated with downregulated dendritic-mediated adaptive immune responses.

[eLife] The authors characterized cell free DNA released from specific immune cell types in healthy individuals, cross sectionally and longitudinally.

[Nature Reviews Gastroenterology & Hepatology] Scientists summarize the role of macrophages, platelets and neutrophils in liver ischaemia–reperfusion injury (LIRI), highlight unanswered questions, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.

[Stem Cell Reports] Scientists identified CD62L as a marker to reveal the heterogeneity within progenitors. They confirmed that CD62L-negative common myeloid progenitors (CMPs) represent “bona fide” CMPs, and CD62L-high CMPs are mostly restricted to granulocyte-monocyte progenitors potentials in mice and humans.