granulocytes

[Cell Death Discovery] Scientists demonstrated that in contrast to radioprotection, neutrophils were essential for the radiomitigative activity of entolimod in a mouse model of lethal acute radiation syndrome. Recombinant MMP-9 by itself had radiomitigative activity and, in the absence of neutrophils, accelerated the recovery of the hematopoietic system.

[Annals of Hematology] The authors compared transplantation outcomes between a fludarabine (Flu)- and melphalan-based regimen and a Flu- and cyclophosphamide-based regimen

[Proceedings of the National Academy of Sciences of the United States of America] The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.

[Scientific Reports] The authors investigated the utility of zebrafish larvae to model the effect of exogenous glucose on neutrophil and macrophage recruitment to a tail wound, wound-induced hemostasis, and chicken egg yolk feed challenge-induced hyperlipidaemia by supplementing larvae with exogenous glucose by immersion or injection.

[Bone Marrow Transplantation] Investigators aimed to modify the immune response in the long term after allogeneic bone marrow transplantation by using the proteasome inhibitor ixazomib at the late stages of the post-transplant period.

[Stem Cell Research & Therapy] Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.