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granulocytes

ADRB3 Induces Mobilization and Inhibits Differentiation of Both Breast Cancer Cells and Myeloid-Derived Suppressor Cells

[Cell Death & Disease] ADRB3 promoted metastasis by inducing mobilization and inhibiting differentiation of both breast cancer cells and myeloid-derived suppressor cells.

Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis

[Arteriosclerosis Thrombosis and Vascular Biology] Scientists discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology.

NF-κB Perturbation Reveals Unique Immunomodulatory Functions in Prx1+ Fibroblasts That Promote Development of Atopic Dermatitis

[Science Translational Medicine] Investigators examined human atopic dermatitis (AD) skin samples and found that human AD fibroblasts also overexpressed C-C motif chemokine ligand 11 (CCL11) and that perturbation of Ikkb–NF-κB in primary human dermal fibroblasts up-regulated CCL11.

Impaired Neutrophil Extracellular Trap Formation in β-Thalassaemia/HbE

[Scientific Reports] The authors demonstrated abnormalities of neutrophil function, namely neutrophil extracellular trap formation in splenectomised and non-splenectomised β-thalassaemia/HbE patients who had iron overload.

Tumor Cell Apoptosis Modulates the Colorectal Cancer Immune Microenvironment via Interleukin-8-Dependent Neutrophil Recruitment

[Cell Death & Disease] The authors investigated the impact of apoptotic colorectal cancer cells on neutrophils and its consequence on other immune cells of the tumor microenvironment.

Lipoxins Modulate Neutrophil Oxidative Burst, Integrin Expression and Lymphatic Transmigration Differentially in Human Health and Atherosclerosis

[FASEB Journal] Scientists evaluated the effects of the specialized pro-resolving mediators lipids, lipoxin A4 and lipoxin B4, on neutrophils isolated from patients with atherosclerosis compared with healthy controls.

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