hedgehog pathway

[Oncology Reports] Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.

[Brain] Researchers showed that the CNS-endogenous hedgehog pathway attenuated the pathogenicity of human and mouse effector CD4 T cells by regulating their production of inflammatory cytokines.

[Cell Death & Disease] Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.

[Journal of Clinical Investigation] Scientists identified resistance mechanisms to CDK6 inhibition in Hedgehog (HH)-associated medulloblastoma by performing orthogonal CRISPR and CRISPR interference screens in medulloblastoma cells treated with a CDK4/6 inhibitor, and RNA-sequencing of a mouse model of HH-associated medulloblastoma with genetic deletion of Cdk6.

[Cell Death & Disease] Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.

[Acta Pharmacologica Sinica] Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.