hedgehog signaling

[Cancer Medicine] Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.

[Brain] Researchers showed that the CNS-endogenous hedgehog pathway attenuated the pathogenicity of human and mouse effector CD4 T cells by regulating their production of inflammatory cytokines.

[Nature Genetics] Scientists discovered evidence of lineage-specific selection on the hedgehog signaling pathway, including a human-specific sixfold down-regulation of EVC2, a key hedgehog gene.

[Cancer Science] Investigators found that GPR126 had higher expression in most colorectal cancer cell lines than in normal colon epithelial cell lines, and higher expression levels in colorectal cancer tissues than in normal adjacent colon tissues.

[Journal of Clinical Investigation] Scientists identified resistance mechanisms to CDK6 inhibition in Hedgehog (HH)-associated medulloblastoma by performing orthogonal CRISPR and CRISPR interference screens in medulloblastoma cells treated with a CDK4/6 inhibitor, and RNA-sequencing of a mouse model of HH-associated medulloblastoma with genetic deletion of Cdk6.

[Oncogene] The authors demonstrated a novel mechanism for activation of GLI-mediated signaling in epithelial breast tumor cells via epithelial-to-mesenchymal transition (EMT) cell-induced production and secretion of VEGF-C.