hematopoietic stem cells

[Blood] By combining fluorescent biosensors with time-lapse imaging and microfluidics, researchers measured the activity of the extracellular signal-regulated kinase pathway over time in live single human umbilical cord blood HSCs and multipotent progenitor cells.

[Tissue Engineering Part B-Reviews] Investigators highlight the influence of hematopoeitic stem cells in the bone repair process, mainly through the promotion of osteogenesis and angiogenesis at the bone injury site.

[Communications Biology] Scientists showed that while AMD11070 acts as a full antagonist, plerixafor acts biased by stimulating β-arrestin recruitment while fully antagonizing G protein.

[Blood Reviews] Scientists summarize the current knowledge on the biochemical characteristics of quiescent hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs), the intracellular signaling pathways and the niche-driven mechanisms that control quiescence and the key differences between HSC- and LSC-quiescence.

[New England Journal of Medicine] Scientists treated 50 patients with Severe combined immunodeficiency due to adenosine deaminase (ADA) with an investigational gene therapy composed of autologous CD34+ hematopoietic stem and progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA.

[Proceedings of the National Academy of Sciences of the United States of America] CD34+ cells derived in vitro from induced pluripotent stem (iPS) cells genetically modified to carry the CCR5Δ32 mutant alleles did not engraft in humanized immunodeficient mice.