hematopoietic stem cells

[Nature Medicine] Through integrative molecular profiling of HSCs and progenitor cells in large patient cohorts, scientists found that myelodysplastic syndromes HSCs in two distinct differentiation states were maintained throughout the clinical course of the disease.

[Periodontology 2000] The authors review two newly emerged concepts, trained innate immunity and clonal hematopoiesis of indeterminate potential, which together support a potential hypothesis on how periodontitis affects and is affected by comorbidities and why the susceptibility to periodontitis and comorbidities increases with aging.

[Nature Cell Biology] Scientists showed that VCAM1 was also expressed on healthy haematopoietic stem cells and upregulated on leukaemic stem cells, where it served as a quality-control checkpoint for entry into bone marrow by providing ‘don’t-eat-me’ stamping in the context of major histocompatibility complex class-I presentation.

[Haematologica] By combining single cell analyses and P53 conformation-specific monoclonal antibodies scientists studied pre-leukemic-HSCs/progenitor cells from primary human DNMT3A-mutated AML samples.

[Bone Marrow Transplantation] Scientists investigated whether gilteritinib, a selective FLT3 inhibitor, could enhance graft-versus-leukemia effects against FLT3 internal tandem duplication mutant transfected Ba/F3 leukemia in mice.

[EMBO Journal] Scientists provided novel insights into HSC regulation during regeneration by focusing on mitochondrial metabolism and ATP citrate lyase.