hepatic cells

[Journal of Nanobiotechnology] Researchers isolated extracellular microparticles derived from apoptotic hepatic progenitor cells and tested their ability to inhibit hepatocarcinogenesis.

[Xenotransplantation] Human MSCs derived from umbilical cord tissue were transdifferentiated into hepatocyte-like cells using patient-derived serum along with dimethyl sulfoxide.

[Cancer Gene Therapy] In hepatic cells, Dicer deletion delivered distinct lipid profile and increased lipid oxidation. Mechanically, Dicer deletion caused declined miR-192-3p and increased IGF2 in hepatocytes.

[Signal Transduction and Targeted Therapy] A novel ionizable lipidoid nanoparticle and a state-of-the-art lyophilization technology were developed, enabling to deliver small interfering RNA (siRNA) targeting apolipoprotein B into the hepatocytes with an ED50 of 0.05 mg/kg after intravenous injection.

[Chemosphere] The authors demonstrated that mono-2-ethylhexyl phthalate (MEHP) exposure inhibited the expression of STAT5A by causing oxidative damage in BRL-3A hepatocytes, thus accelerating the expression of key molecules in fibrosis and promoting the occurrence of liver fibrosis.

[PLoS Pathogens] Similar to other filoviruses, recombinant Lloviu virus formed filamentous virions and induced the formation of characteristic inclusions in the cytoplasm of the infected cells, as shown by electron microscopy.