hepatic cells

[PLoS One] Scientists characterized hepatic stellate cells obtained from patients carrying the wild type and the heterozygous or homozygous PNPLA3 I148M and investigated the effect of genotype and PNPLA3 downregulation on baseline and TGF-β-stimulated fibrotic gene expression.

[PLoS One] Activated hepatic stellate cell cell lines were used to evaluate the effects of tenofovir disoproxil fumarate and entecavir. After treatment with each antiviral agent, cell viability, morphology, apoptotic features, autophagy and antifibrosis signaling pathways were examined.

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

[Hepatology] The authors invevstigated whether farnesoid X receptor (FXR) played a role in regulating iron hepatotoxicity and found that iron suppressed FXR expression and signaling in human and mouse hepatocytes as well as in mouse liver and intestine.

[Cell Death & Disease] Scientists demonstrated that stiffness contributed to mechanosignal transduction in hepatic stellate cells, which promoted hepatocellular carcinoma cells growth and metastasis through secretion of FGF2.

[Cell Death Discovery] Researchers investigated the molecular mechanisms underlying the effect of berberine against liver fibrogenesis in thioacetamide and carbon tetrachloride induced mouse liver fibrosis.