in silico

[Molecular Therapy-Nucleic Acids] Initial in silico analysis predicted exons that can be skipped with minimal loss of neurofibromin function, which was confirmed with in vitro assessments utilizing an neurofibromatosis type 1 (Nf1) cDNA-based functional screening system.

[Scientific Reports] Investigators discovered a mechanical correlation between leucine proline-enriched proteoglycan 1 (LEPRE1) and pelitinib drug sensitivity using in silico statistical methods and confirmed the correlation in acute myeloid leukemia and A549 lung cancer cells.

[Scientific Reports] To identify novel drug targets and uncover potential mechanisms by which these drugs attenuate fibrosis, scientists performed an integrative ‘omics analysis of transcriptomic and proteomic responses to TGFβ1-stimulated lung fibroblasts.

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

[Molecular Diversity] Researchers observed kaempferol and apigenin inhibited cellular proliferation by DNA damage and S-phase cell cycle arrest in TNBC Cells.