in silico

[Prostate Cancer and Prostatic Diseases] Researchers used screening tests for candidate drugs targeting cabazitaxel (CBZ)-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in castration-resistant prostate cancer.

[Scientific Reports] Gastric cancer (GC) is one of the most lethal malignant tumors. Researchers identified novel driver genes and clarified their roles in GC.

[Aging] Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.

[Nature Communications] Since Wiskott–Aldrich Syndrome protein (WASp) is exclusively expressed in hematopoietic cells, scientists performed in silico screening to identify small molecule compounds that bound WASp and promoted its degradation.

[Cellular Signalling] Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.

[Journal of Biomolecular Structure and Dynamics] Scientists investigated the potential of using a marine triterpenoid saponin, holothurin A, on targeting androgen receptor expression of prostate cancer using in vitro and in silico studies.