in silico

[Experimental and Molecular Medicine] Researchers found that cytochrome c oxidase subunit 5a expression was noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulated other identified proteins and was closely related to hypoxia-induced cell death.

[Cell Death & Disease] In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.

[International Journal of Biological Macromolecules] Scientists reported the molecular interactions of indoline derivative, HIC, with P2Y1R. In vitro analysis has shown increased apoptosis of PCa-cells, PC3, and DU145, upon specific interaction of P2Y1R-HIC.

[npj Breast Cancer] Exogenous leptin abrogated tamoxifen-mediated growth inhibition and potentiated breast tumor growth even in the presence of tamoxifen.

[Science] A combination of single-cell transcriptomic profiling, in silico lineage tracing from methylation, open chromatin and somatic mutation analyses, and functional studies in organoid models showed that Barrett’s esophagus originated from gastric cardia through c-MYC and HNF4A-driven transcriptional programs.

[Cell Death & Disease] ENC1-SEdistal deletion reduced ENC1 expression and inhibited the malignant behavior of breast carcinoma cells and their resistance to radiotherapy.