Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsA combination of single-cell transcriptomic profiling, in silico lineage tracing from methylation, open chromatin and somatic mutation analyses, and functional studies in organoid models showed that Barrett’s esophagus originated from gastric cardia through c-MYC and HNF4A-driven transcriptional programs.
[Science]
6445212 F899CM9X items 1 apa 0 default asc 1 165674 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d41cd853761075f31e2f5c42544e17da%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22F899CM9X%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nowicki-Osuch%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-13%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENowicki-Osuch%2C%20K.%2C%20Zhuang%2C%20L.%2C%20Jammula%2C%20S.%2C%20Bleaney%2C%20C.%20W.%2C%20Mahbubani%2C%20K.%20T.%2C%20Devonshire%2C%20G.%2C%20Katz-Summercorn%2C%20A.%2C%20Eling%2C%20N.%2C%20Wilbrey-Clark%2C%20A.%2C%20Madissoon%2C%20E.%2C%20Gamble%2C%20J.%2C%20Pietro%2C%20M.%20D.%2C%20O%26%23x2019%3BDonovan%2C%20M.%2C%20Meyer%2C%20K.%20B.%2C%20Saeb-Parsy%2C%20K.%2C%20Sharrocks%2C%20A.%20D.%2C%20Teichmann%2C%20S.%20A.%2C%20Marioni%2C%20J.%20C.%2C%20%26amp%3B%20Fitzgerald%2C%20R.%20C.%20%282021%29.%20Molecular%20phenotyping%20reveals%20the%20identity%20of%20Barrett%26%23x2019%3Bs%20esophagus%20and%20its%20malignant%20transition.%20%3Ci%3EScience%3C%5C%2Fi%3E%2C%20%3Ci%3E373%3C%5C%2Fi%3E%286556%29%2C%20760%26%23x2013%3B767.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscience.abd1449%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscience.abd1449%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DF899CM9X%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecular%20phenotyping%20reveals%20the%20identity%20of%20Barrett%5Cu2019s%20esophagus%20and%20its%20malignant%20transition%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karol%22%2C%22lastName%22%3A%22Nowicki-Osuch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lizhe%22%2C%22lastName%22%3A%22Zhuang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sriganesh%22%2C%22lastName%22%3A%22Jammula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20W.%22%2C%22lastName%22%3A%22Bleaney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Krishnaa%20T.%22%2C%22lastName%22%3A%22Mahbubani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ginny%22%2C%22lastName%22%3A%22Devonshire%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annalise%22%2C%22lastName%22%3A%22Katz-Summercorn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nils%22%2C%22lastName%22%3A%22Eling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Wilbrey-Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elo%22%2C%22lastName%22%3A%22Madissoon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Gamble%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Massimiliano%20Di%22%2C%22lastName%22%3A%22Pietro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22O%5Cu2019Donovan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%20B.%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kourosh%22%2C%22lastName%22%3A%22Saeb-Parsy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%20D.%22%2C%22lastName%22%3A%22Sharrocks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%20A.%22%2C%22lastName%22%3A%22Teichmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20C.%22%2C%22lastName%22%3A%22Marioni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecca%20C.%22%2C%22lastName%22%3A%22Fitzgerald%22%7D%5D%2C%22abstractNote%22%3A%22Identifying%20the%20origin%20of%20cancer%5CnMany%20cancers%20are%20classified%20on%20the%20basis%20of%20the%20organ%20or%20tissue%20from%20which%20they%20originated.%20However%2C%20identifying%20the%20specific%20cells%20and%20conditions%20that%20precede%20tumorigenesis%20can%20help%20us%20understand%20and%20better%20treat%20the%20resulting%20disease.%20Nowicki-Osuch%20et%20al.%20used%20a%20single-cell%20approach%20to%20investigate%20the%20cell%20of%20origin%20for%20Barrett%27s%20esophagus%20%28BE%29%20and%20the%20mechanisms%20leading%20to%20the%20development%20of%20esophageal%20adenocarcinoma%20%28EAC%29%20%28see%20the%20Perspective%20by%20Geboes%20and%20Hoorens%29.%20Analyses%20of%20healthy%20human%20esophageal%20tissues%2C%20mutational%20lineage%20tracing%2C%20and%20organoid%20models%20revealed%20that%20BE%20originates%20from%20the%20gastric%20cardia%20and%20that%20EAC%20arises%20from%20undifferentiated%20BE%20cells.%20This%20analysis%20provides%20a%20map%20of%20the%20transcriptional%20landscape%20of%20the%20healthy%20esophagus%20that%20can%20be%20compared%20with%20mouse%20models%20of%20disease.%5CnScience%2C%20abd1449%2C%20this%20issue%20p.%20760%3B%20see%20also%20abj9797%2C%20p.%20737%5CnThe%20origin%20of%20human%20metaplastic%20states%20and%20their%20propensity%20for%20cancer%20is%20poorly%20understood.%20Barrett%5Cu2019s%20esophagus%20is%20a%20common%20metaplastic%20condition%20that%20increases%20the%20risk%20for%20esophageal%20adenocarcinoma%2C%20and%20its%20cellular%20origin%20is%20enigmatic.%20To%20address%20this%2C%20we%20harvested%20tissues%20spanning%20the%20gastroesophageal%20junction%20from%20healthy%20and%20diseased%20donors%2C%20including%20isolation%20of%20esophageal%20submucosal%20glands.%20A%20combination%20of%20single-cell%20transcriptomic%20profiling%2C%20in%20silico%20lineage%20tracing%20from%20methylation%2C%20open%20chromatin%20and%20somatic%20mutation%20analyses%2C%20and%20functional%20studies%20in%20organoid%20models%20showed%20that%20Barrett%5Cu2019s%20esophagus%20originates%20from%20gastric%20cardia%20through%20c-MYC%20and%20HNF4A-driven%20transcriptional%20programs.%20Furthermore%2C%20our%20data%20indicate%20that%20esophageal%20adenocarcinoma%20likely%20arises%20from%20undifferentiated%20Barrett%5Cu2019s%20esophagus%20cell%20types%20even%20in%20the%20absence%20of%20a%20pathologically%20identifiable%20metaplastic%20precursor%2C%20illuminating%20early%20detection%20strategies.%5CnGastric%20cardia%20cells%20give%20rise%20to%20Barrett%5Cu2019s%20esophagus%2C%20which%20in%20turn%20can%20develop%20into%20esophageal%20adenocarcinoma.%5CnGastric%20cardia%20cells%20give%20rise%20to%20Barrett%5Cu2019s%20esophagus%2C%20which%20in%20turn%20can%20develop%20into%20esophageal%20adenocarcinoma.%22%2C%22date%22%3A%222021%5C%2F08%5C%2F13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscience.abd1449%22%2C%22ISSN%22%3A%220036-8075%2C%201095-9203%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fscience.sciencemag.org%5C%2Fcontent%5C%2F373%5C%2F6556%5C%2F760%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-13T17%3A35%3A30Z%22%7D%7D%5D%7D
Nowicki-Osuch, K., Zhuang, L., Jammula, S., Bleaney, C. W., Mahbubani, K. T., Devonshire, G., Katz-Summercorn, A., Eling, N., Wilbrey-Clark, A., Madissoon, E., Gamble, J., Pietro, M. D., O’Donovan, M., Meyer, K. B., Saeb-Parsy, K., Sharrocks, A. D., Teichmann, S. A., Marioni, J. C., & Fitzgerald, R. C. (2021). Molecular phenotyping reveals the identity of Barrett’s esophagus and its malignant transition. Science, 373(6556), 760–767. https://doi.org/10.1126/science.abd1449 Cite
