induced pluripotent stem cells

[Inflammatory Bowel Diseases] Human intestinal organoids expressed core mitochondrial and ECM genes and enriched biologic functions implicated in Crohn’s disease ileal strictures; ECM gene expression was suppressed by both butyrate and eicosatetraynoic acid, with butyrate also suppressing genes regulating epithelial proliferation.

[Advanced Materials] The authors presented the synthesis and characterization of a new biobased nanohybrid elastomer which was electrospun into aligned nanofiber sheets to mimic the skeletal muscle extracellular matrix.

[Stem Cell Reports] Scientists described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.

[Nature Genetics] Scientists employed DNA fiber analysis to investigate how PSCs are reprogrammed into totipotent-like 2-cell-like cells (2CLCs) and showed that totipotent cells of the early mouse embryo had slow DNA replication fork speed and that 2CLCs recapitulated this feature.

[American Journal of Physiology-Cell Physiology] The authors discuss the latest research on long non-coding RNAs in iPSC stemness, neuronal, and cardiac differentiation.

[Journal of the American Society of Nephrology] Scientists used CRISPR-Cas9 gene editing of iPSCs to develop humanderived APOL1G0/G0 and APOL1G2/G2 kidney organoids on an isogenic background, and performed bulk RNA sequencing of organoids before and after treatment with IFN-γ.