Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

Human intestinal organoids expressed core mitochondrial and ECM genes and enriched biologic functions implicated in Crohn’s disease ileal strictures; ECM gene expression was suppressed by both butyrate and eicosatetraynoic acid, with butyrate also suppressing genes regulating epithelial proliferation.