induced pluripotent stem cells

[Stem Cells] Investigators demonstrated that treatment of liver fibrosis with both human induced pluripotent stem cell-derived macrophage populations and especially M2 subtype significantly reduced fibrogenic gene expression and disease associated histological markers in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.

[Stem Cell Reports] Exposure of human pluripotent stem cell-derived cardiomyocytes and primary endothelial cells to SARS-CoV-2 identified significant differences in protein coding genes involved in immunity, viral response, and cardiomyocyte/endothelial structure.

[Aging Cell] Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.

[Cancer Letters] Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.

[Nature Communications] Investigators generated a induced pluripotent stem cell Alzheimer's disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.

[Nature Communications] Investigators utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of Autism Spectrum Disorder with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development.