induced pluripotent stem cells

[Scientific Reports] Researchers investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.

[Journal of Bioscience and Bioengineering] A culture system with bubble sparging for human iPSC proliferation was designed using a plastic fluid as a culture medium.

[Stem Cell Research] Researchers generated three human-iPSC lines from peripheral blood mononuclear cells of two long QT syndrome type 2 (LQT2) patients carrying pathogenic variants and one LQT2 patient carrying a variant of uncertain significance in KCNH2.

[Bioinformatics] Researchers used a commercial maturation medium intended to promote the maturation status of human iPSC-cardiomyocytes, and compared the parameters with the ones obtained with standard culture medium, and with freshly dissociated mouse cardiomyocytes.

[Stem Cell Reports] Researchers generated patient-specific induced pluripotent stem cell-derived atrial cardiomyocytes to characterize the pathogenesis of AF-linked SCN5A mutations.

[Stem Cell Reports] Investigators provided mechanistic insights into the proliferation-independent telomere shortening in cardiomyocytes of a Duchenne muscular dystrophy mouse model using human induced pluripotent stem cell-derived cardiomyocytes.